Thermal lesions of the SCN do not abolish all gene expression rhythms in rat white adipose tissue, <i>NAMPT</i> remains rhythmic

Obesity and type 2 diabetes mellitus are major health concerns worldwide. In obese-type diabetic patients, the function of central brain clock in hypothalamus, as well rhythmicity white adipose tissue (WAT), reduced. To better understand how peripheral clocks (WAT) synchronized, we assessed importance for daily WAT rhythms. We compared gene expression rhythms core genes (Bmal1, Per2, Cry1, Cry2, RevErbα, DBP) metabolic (SREBP1c, PPARα, PPARγ, FAS, LPL, HSL, CPT1b, Glut4, leptin, adiponectin, visfatin/NAMPT, resistin) epididymal subcutaneous (eWAT sWAT) SCN-lesioned sham-lesioned rats housed regular L/D conditions. Despite complete behavioral hormonal arrhythmicity, SCN lesioning only abolished Cry2 DBP WAT, whereas other were significantly reduced, but not completely abolished. observed no differences effect lesions between two depots. contrast to genes, all lost their with exception NAMPT. Interestingly, NAMPT was even less affected by than suggesting that it is either strongly coupled remaining expression, or very sensitive external rhythmic factors. The cycle could be such a factor generates modulating signals photic masking via intrinsic photosensitive retinal ganglion cells combination autonomic nervous system. Our findings indicate normal weight rats, can maintained independent clock.